Association of obesity and insulin resistance to gestational diabetes mellitus

Abstract

Gestational diabetes mellitus is most commonly observed in pregnant women and it was significantly linked with dyslipidemia, obesity and insulin resistance. The present study aimed to evaluate the association of obesity, insulin resistance risk of gestational diabetes mellitus. This cross sectional study included total ninety (90) subjects out of this 30 subjects with 1st trimester, another 30 subjects were considered 2nd trimester and remaining 30 were 3rd trimester. The fasting, post parandial blood sugars, glycated haemoglobin, lipid profile and insulin levels were measured and data was recorded. There was a significantly elevated levels of fasting and post parandial blood sugars, glycated haemoglobin, total cholesterol, triacylglycerol, very low density lipoprotein, low density lipoprotein (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. Additionally, we also observed significantly decreased levels of high density lipoprotein, insulin and HOMA-IR (p = 0.0001**) in all the trimesters of gestational diabetes mellitus subjects. The present study IR raises as the pregnancy progresses and it is linked to bad outcomes for both the mother and the fetus. All trimesters of gestational diabetes mellitus should be screened for IR, and early treatment may assist to lessen the resulting difficulties.