Effect of Pistacia lentiscus Extract on Dentin Remineralization: An In Vitro Study

Abstract

Background and Aim: This study aimed to assess the efficacy of Pistacia lentiscus (P. lentiscus) extract for dentin remineralization. Materials and Methods: This in vitro experimental study evaluated 45 extracted sound human premolars; pH cycling was performed to assess the effect of 10% P. lentiscus extract on dentin remineralization. The samples were randomly assigned to three groups of 1000 ppm sodium fluoride (NaF) solution, 10% P. lentiscus extract, and deionized water. To induce dentinal lesions, the teeth were immersed in a demineralizing solution at 37°C for 96 hours. The demineralized samples were then subjected to pH cycling for 14 days, and then underwent the Vickers microhardness test and scanning electron microscopic (SEM) assessment. Data were analyzed by repeated-measures ANOVA. Results: The mean microhardness in the NaF group was significantly higher than that in the extract and control groups after 14 days (P<0.05). SEM assessment after demineralization indicated tubular obstruction in the extract and NaF groups. However, after 14 days, the sealing of dentinal tubules in the extract group was greater than that in the NaF group. Conclusion: P. lentiscus extract can serve as a suitable organic compound for dentinal tubule occlusion as well as non-invasive and conservative treatment of dentin hypersensitivity (DH).