Development of wound dressing with sustained-release of drug using natural polymer

Abstract

In recent years, wound management based on moist healing is getting popular because moist healing is to induce the ability of natural healing by keeping moist that contain many kinds of substances from the biological fluid. A suitable material for moist healing is hydrogel dressing, however it can't adsorb a therapeutic agent in general. In this study, a wound healing dressing providing sustained release of fradiomycin sulfate was prepared using chitosan nanofiber and sodium alginate composite. Gauze coated with chitosan nanofiber and sodium alginate (CAG) forms polyion complex by calcium cross-linkage which has a hemostatic effect. The resultant CAG demonstrated sufficient mechanical properties, water absorption, and biocompatibility as for wound healing dressing, and the optimum weight mixing ratio of chitosan and alginate was set to 6:4. The chitosan nanofiber and CAG adsorbed fradiomycin sulfate in a manner of monolayer. The fradiomycin sulfate adsorbed to CAG was gradually released at a constant rate in PBS (phosphate buffer solution).