Polymorphism in an amyloid-like fibril-forming model peptide

Abstract

(Figure Presented) The structural basis for polymorphism in amyloids is unraveled with a model system. The hydrogen-bonding pattern within the β sheets of fibrils is strongly influenced by the pH of the solution from which the fibrils are formed. Solid-state NMR spectroscopy experiments allow quantification of the relative amounts of two different β-sheet structures over the pH range 2.0-7.3. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.