Left ventricular mass index as a predictor of new-onset microalbuminuria in hypertensive subjects: A prospective study

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Abstract

BackgroundWe aimed to investigate the predictive role of left ventricular mass and its reduction on the development of new-onset microalbuminuria (MA) in newly diagnosed hypertensive patients.MethodsA total of 207 nondiabetic, normoalbuminuric patients without clinical organ damage (aged 50.8 ± 10.1 years, 132 male, 84 smokers) with baseline office blood pressure (BP) 148/96 mm Hg were followed for a mean period of 3.3 ± 1.3 years. At baseline and last follow-up visit, all patients underwent office and 24-h ambulatory BP monitoring, albumin to creatinine ratio (ACR) determination, and echocardiographic assessment of left ventricular mass index (LVMI). All patients were treated with antihypertensive therapy during the follow-up period. We defined MA as ACR between 20 and 300 mg/g for men and 30300 mg/g for women, effective BP control as office BP 140/90 mm Hg in ≥75% of total number of visits, and LVMI reduction as the decline of LVMI at end-follow-up of 15% with respect to the baseline value.ResultsBetween baseline and last follow-up visit, LVMI decreased by 6.84 ± 21.5 g/m2 (P<0.01); 64.3% (n = 133) of participants achieved BP control during the follow-up period. Of the total population, 5.8% (n = 12) developed MA during follow-up. Cox-regression analysis, after adjustment for clinical variables, revealed that increase of LVMI by 1 s.d. (23.3 g/m2) conferred a 15% increased risk of new-onset MA, while LVMI reduction and BP control were both associated with almost 100% reduced risk of MA development.ConclusionsLVMI and its reduction were qualified as predictors of new-onset MA in newly diagnosed hypertensive patients, beyond BP control. © 2012 American Journal of Hypertension, Ltd.

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Andrikou, E., Tsioufis, C., Thomopoulos, C., Andrikou, I., Kasiakogias, A., Leontsinis, I., … Stefanadis, C. (2012, November). Left ventricular mass index as a predictor of new-onset microalbuminuria in hypertensive subjects: A prospective study. American Journal of Hypertension. https://doi.org/10.1038/ajh.2012.109

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