Abstract
A novel biocatalytic protocol for C -C bond formation is described and is an equivalent to Friedel-Crafts alkylation. S-Adenosyl-L-methionine (SAM), the major Chemical Equation Presentation methyl donor for biological methylation catalyzed by methyltransferases (Mtases), can perform alkylations (see scheme). These enzymes can accept non-natural cofactors and transfer functionalities other than methyl onto aromatic substrates © 2009 Wiley-VCH Verlag GmbH Co. KCaA.
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Stecher, H., Tengg, M., Ueberbacher, B. J., Remler, P., Schwab, H., Griengl, H., & Gruber-Khadjawi, M. (2009). Biocatalytic Friedel-Crafts alkylation using non-natural cofactors. Angewandte Chemie - International Edition, 48(50), 9546–9548. https://doi.org/10.1002/anie.200905095
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