Apoptosis, proliferation, and cell size in seasonal changes of body and organ weight in male bank voles Myodes glareolus

Abstract

Adult male bank voles undergo the body and organ regression before winter, and in early spring, they resume the growth and reproductive processes. The aim of the present study was to determine whether the seasonal changes of body and organ weight in these animals depend on changes in the number of cells or their size. To study an autumnal regression, wild adult males captured in August were exposed to short photoperiod for 0, 4, and 8 weeks, while to study a spring resumption, overwintered males caught in March were exposed to long photoperiod for 0, 1, and 4 weeks. Apoptosis, proliferation, and cell size in the skeletal muscles, liver, and testes were examined. The study revealed that the seasonal changes of testes weight were associated with changes in the number of testicular cells. On the contrary, the changes in size of skeletal myocytes and hepatocytes appeared to be responsible for the seasonal changes of body (muscle) and liver weights in these rodents.