Abstract
Pyrazinamide (PZA) is an important component of first-line therapy for the treatment of tuberculosis. Here, we evaluate targeted gene sequencing as a supplement to phenotypic PZA susceptibility testing of Mycobacterium tuberculosis. Routine sequencing of pncA, but not rpsA, is effective for verification of PZA susceptibility results. Copyright © 2012, American Society for Microbiology. All Rights Reserved.
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CITATION STYLE
Alexander, D. C., Ma, J. H., Guthrie, J. L., Blair, J., Chedore, P., & Jamieson, F. B. (2012). Gene sequencing for routine verification of pyrazinamide resistance in Mycobacterium tuberculosis: A role for pncA but not rpsA. Journal of Clinical Microbiology, 50(11), 3726–3728. https://doi.org/10.1128/JCM.00620-12
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