Is this really just “fatigue”? A case series of immune-related central adrenal insufficiency secondary to immune checkpoint inhibitors

Abstract

While immunotherapy with programmed cell death protein 1 (PD1) checkpoint inhibition has shown promising activity against many tumor types, adverse events are common. Hypophysitis is a rare but serious immune-related event known to occur with anti-PD1 inhibition. It will become more prevalent as the usage of checkpoint inhibitors increases.