Synthesis of some novel fluorinated 4-thiazolidinones containing amide linkages and their antimicrobial screening

Abstract

Efficient syntheses of some 4-thiazolidinones are described. A series of 2-(substituted phenyl)-3-[4-(2,4-dichloro-5-fluorophenyl)-6-(2-thienyl) pyrimidine-2-yl-ureido]-5H/methyl/carboxymethyl-4-thiazolidinones 5a-e,6a-e,7a-e were prepared. The structures of the synthesised compounds were assigned on the basis of elemental analysis, IR and 1H NMR spectral data. All the products were screened against different strains of bacteria and fungi. ©ARKAT USA, Inc.