Dissolution testing of single-and dual-component thyroid hormone supplements

Abstract

A method for the analysis of thyroid hormones by liquid chromatography-mass spectrometry was used for the dissolution testing of single-and dual-component thyroid hormone supplements via a two-stage biorelevant dissolution procedure. The biorelevant media consisted of fasted-state simulated gastric fluid and fasted state simulated intestinal fluid at 37◦ C, and was investigated using an internationally recognized protocol. The dissolution profiles showed consistent solubilization for both single-and dual-component batches at pH 6.5 in the fasted-state simulated intestinal fluid.