Vignoside, a novel new sesquiterpene glucoside obtained from a hot-water extract of adzuki bean (Vigna angularis)

Abstract

We have found that a hot-water extract from adzuki beans inhibited the growth of human stomach cancer KATO III cells. In this study, the active components were isolated from the extract by repeated reverse phase chromatographic purification. The structures of the isolated growth inhibitors were elucidated by FT-IR, 1D and 2D NMR, and ESI-MS and APCI-MS analyses. They were novel sesquiterpene glucosides, which were a pair of isomers interconvertible to each other at high temperature. We named these novel sesquiterpene glucosides Vignoside A and B.