Abstract
1H-Imidazo[2,1-a]isoindole-2,5(3H,9bH)-diones 6a-i are synthesized in 67-96% yields with high stereoselectivities (de 88-99%, except 6e with a 58% de value) via intermolecular condensation of 2-formylbenzoic acid (5) and a-amino amides 4a-i in the presence of a catalytic amount of toluene-p-sulfonic acid. Intermediates 4 are obtained in two steps from easily available chiral N-Boc-a-amino acids 1. © 2001 The Royal Society of Chemistry.
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CITATION STYLE
Schobert, A. R., Xu, Y. J., He, H. Y., & Steel, P. J. (2001). Stereoselective syntheses of 1H-imidazo[2,1-a]isoindole-2,5(3H,9bH)-diones. Journal of the Chemical Society. Perkin Transactions 1, 1(15), 1767–1770. https://doi.org/10.1039/b104060j
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