A role for autoinhibition in preventing dimerization of the transcription factor ETS1

Abstract

Background: The transcription factor ETS1 controls its DNA binding activity through an autoinhibitory module. Results: The relationship between specific and nonspecific DNA binding, homodimer formation, and autoinhibition was explored. Conclusion: ETS1 transiently forms dimers as a consequence of interacting with any DNA sequence. Significance: Relief of autoinhibition by nonspecific DNA interaction leading to subsequent ETS1 dimerization may represent a conserved element of DNA recognition across the ETS family.