Teichomycins, new antibiotics from actinoplanes teichomyceticus nov. Sp.: IV. Separation and characterization of the components of teichomycin (teicoplanin)

Abstract

Teichomycin (teicoplanin) was found to be a mixture of five closely related components of similar polarity, designated T-A2-1, 2, 3, 4 and 5 and of one more polar component, designated T-A3. The separation of the single components was achieved by reverse phase partition chromatography and their physicochemical and biological properties were compared. The results show that 1) the five major components have the same molecular size of about 1,900; 2) they contain the same ionizable functions, i.e., a carboxyl group and an amino group which form a zwitterion, and four phenolic groups; 3) they differ in a side aliphatic chain. The component T-A3 is not described. © 1984, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.