Making Molecular and Macromolecular Helical Tubes: Covalent and Noncovalent Approaches

Abstract

Aromatic foldamers possess well-defined cavity that can be stabilized by discrete intramolecular interactions including hydrogen bonding, solvophobicity, electrostatic repulsion, or coordination. Long foldamers can form dynamic deep helical tubular architectures that are not only structurally attractive but also useful hosts for guest encapsulation, chirality induction, delivery, and catalysis. This kind of helical tubular structures can be formed by single molecules or macromolecules or by connecting short-folded or helical segments through noncovalent or covalent forces. This perspective summarizes the recent advances on the construction of helical tubes and their properties and functions.