Is the interleukin 8 promoter polymorphism rs4073/-251T >a associated with clostridium difficile infection?

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI. © 2014 The Author.