Experimental animal models used to develop polycystic ovarian syndrome

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of reproductive age. Obesity, dyslipidemia, impaired glucose tolerance and type 2 diabetes are important clinical problems in patients with PCOS. Furthermore, PCOS is a significant risk factor for cardiovascular diseases and endometrial cancer in the long term. Although a number of genetic and environmental factors have been reported in the development, the underlying pathophysiological mechanism remains unclear. In PCOS, which has an active field of research in gynecology, the lack of consensus on the diagnostic criteria leads to be published of contradictory publications on such a frequent systemic disorder. For this reason, it is very important to reveal the exact pathogenesis of the disease with animal models. The purpose of this review is to summarize the experimental models used to induce PCOS. It has been observed that classical polycystic ovarian morphology can be formed in these ovaries by experimental methods and many hormonal imbalances observed in PCOS were noticed.