Oxyfold: A simple and efficient solid-supported reagent for disulfide bond formation

Abstract

The synthesis and use of novel polymer-supported reagents for disulfide bond formation is described. This family of supported reagents consists of a series of oxidized methionines grafted onto a solid support. Their cost and the simplicity of their preparation through N-carboxyanhydride polymerization on beads make them reactants of choice for the formation of disulfide bridges in peptides. Copyright © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.