Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity

  • Santori F
  • Brown S
  • Lu Y
  • et al.
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Abstract

Antagonist-like engagement of the TCR has been proposed to induce T cell selection in the thymus. However, no natural TCR ligand with TCR antagonist activity is presently known. Using a combination of bioinformatics and functional testing we identified the first self-peptide that can both deliver antagonist-like signals and promote T cell selection in the thymus. The peptide is presented by appropriate MHC class I molecules in vivo. Thus, endogenous antagonist peptides exist and may be involved in TCR repertoire selection.

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Santori, F. R., Brown, S. M., Lu, Y., Neubert, T. A., & Vukmanović, S. (2001). Cutting Edge: Positive Selection Induced by a Self-Peptide with TCR Antagonist Activity. The Journal of Immunology, 167(11), 6092–6095. https://doi.org/10.4049/jimmunol.167.11.6092

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