Two novel alkaloids from the South China Sea marine sponge Dysidea sp.

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Abstract

Two new alkaloids, dysideanins A (1) and B (2), along with two known diketopiperazines, cyclo-(Pro-Leu) (3) and cyclo-(Pro-Ile) (4), were isolated from the marine sponge Dysidea sp. The structures were established from NMR and MS analysis. Dysideanin B (2) exhibited antibacterial activity. The thiomethylated imidazolinium unit as found in dysideanin A is very rarely encountered in nature. © 2010 Japan Antibiotics Research Association All rights reserved.

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Ren, S., Ma, W., Xu, T., Lin, X., Yin, H., Yang, B., … Liu, Y. (2010). Two novel alkaloids from the South China Sea marine sponge Dysidea sp. Journal of Antibiotics, 63(12), 699–701. https://doi.org/10.1038/ja.2010.134

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