Regulation of the human ether-a-go-go-related gene (hERG) channel by Rab4 protein through neural precursor cell-expressed developmentally down-regulated protein 4-2 (Nedd4-2)

Abstract

Background: The hERG K+ channel plays an important role in the repolarization of cardiomyocytes where Rab4 is present. Results: Overexpression of Rab4 decreases the density of mature hERG channels. This effect is mediated through enhanced expression of the ubiquitin ligase Nedd4-2. Conclusion: Rab4 regulates hERG channel density via Nedd4-2. Significance: Our data revealed a novel pathway for Nedd4-2 and hERG regulation. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.