Crème de la Kremen of Wnt signalling inhibition

Abstract

Embryonic development depends on spatially regulated signals that function locally to change the fate or shape of cells. Recent advances have shed light on a sophisticated mechanism of Wnt signal inhibition, whereby an activating coreceptor, LDL-receptor-related protein 6 (LRP6), is segregated away by a secreted inhibitor (Dickkopf) and removed by internalization after interaction with the membrane-anchored protein, Kremen.