Recurrent Autoimmune Hepatitis and De Novo Autoimmune Hepatitis in the Liver Allograft

Abstract

Objectives: Autoimmune hepatitis (AIH) is a form of severe hepatitis that can recur after orthotopic liver transplant (OLT). Presentation of AIH in patients with OLT who do not have a history of AIH is called de novo AIH (DNAIH). We evaluated the clinicopathologic characteristics of AIH and DNAIH. Methods: Clinicopathologic and outcome measures of 11 patients with recurrent AIH (RAIH) and 22 with DNAIH identified between 2000 and 2017 were compared. Results: Both cohorts showed female predominance. The mean clinical follow-up was 13 and 7.8 years in the in the RAIH and DNAIH groups, respectively (P =. 1). Moderate portal inflammation was more common in patients with RAIH (64% vs 27%, P =. 043). A trend was observed for more cases of DNAIH showing severe inflammation (36% vs 9%, P =. 09) and submassive necrosis compared with RAIH (23% vs 0%, P =. 086). A trend for more advanced fibrosis was also noted in the RAIH group (27% vs 5%, P =. 059). Three patients with RAIH lost their grafts because of RAIH. Five-year disease-specific graft survival (GS) (P =. 012) and overall GS (P =. 015) were worse in patients with RAIH. Complement component 4d immunohistochemistry was positive in 2 patients with RAIH and 3 with DNAIH but showed no correlation with GS or other parameters. Conclusions: RAIH seems to have a more aggressive clinical course than DNAIH and warrants closer clinical follow-up and aggressive treatment.