A convenient one pot synthesis of highly substituted piperidines through a Michael addition-aldol cyclization sequence

Abstract

A neat and rapid procedure is reported for the synthesis of a variety of (2-aroyl-5-hydroxy-1,3,5-triaryl-4-piperidyl)(aryl)methanone (3a-3g) by the condensation of 2-[(2-oxo-2-arylethyl)anilino]-1-aryl-1-ethanones 1 with different arylidene acetophenone 2 under microwave irradiation. ©ARKAT USA, Inc.