Titanium implant surface modification in physiological serum containing new mixed inhibitor based on poly(vinyl) alcohol/silver nanoparticles/epirubicin

Abstract

The titanium behaviour in physiological serum blank (PS) and containing silver nanoparticles (nAg) and polyvinyl alcohol (PVA) in the absence and presence of epirubicin cytostatic (EPR) was studied by potentiodynamic polarization and electrochemical impedance/admittance spectroscopy. These showed that the electrochemical parameters classically ranged, meaning that the addition of nAg/PVA and epirubicin in physiological serum leads to corrosion current density decline and polarization resistance increase while the conductance is diminished. The induced modifications on titanium surface were highlighted by optical microscopy and atomic force microscopy (AFM) which displayed the specific coating adsorbed on titanium surface. Consequently, nAg/PVA improves the epirubicin effect on titanium surface. Prior to the measurements above mentioned, the interactions between nAg and PVA were studied, showing the nAg/PVA composite formation. Also, the interactions between Cl-ions, epirubicin and nAg were discussed, in order to better understand the influence of nAg/PVA composite on the epirubicin protective performance on the titanium surface.