Perfluorocarbon-Based Oxygen Carriers

Abstract

Artificial oxygen ca obtain a stable mixture. Perfluorocarbons rriers are classified into two broad categories: hemoglobin-based and perfluorocarbon-based. Both provide oxygen transport to tissues. For several decades, perfluorocarbons have been explored as oxygen carriers in a variety of biological applications. Perfluorocarbons are chemically and physiologically inert, have excellent temperature and storage stability, represent little to no infectious danger, are commercially available, and have well-established gas transport qualities. Perfluorocarbons are compounds that have high solubility for many gases, but they are not suitable for direct injection into the vascular system and require emulsification to obtain a stable mixture. Perfluorocarbons may be classified into five categories based on the primary perfluorocarbon backbone utilized in the product: (1) perfluorodecalin, (2) perfluorooctyll bromide, (3) tertbutylperfluorocyclohexane, (4) dodecafluoropentane, and (5) perftoran. When combined with other blood-saving strategies, the use of perfluorocarbon-based oxygen carriers enables the performance of surgical procedures with increased blood loss while eliminating or lowering the need for allogeneic transfusion. Other applications have been described and are under investigation.