Matrix metalloproteinases in pancreatitis: current insights

Abstract

Matrix metalloproteinases (MMPs) belong to a family of zinc-dependent endopeptidases belonging to the metzincin superfamily of metalloproteinases. MMPs can degrade most of the constituents of the extracellular matrix, basement membrane, and inflammatory mediators. Most of the MMPs are not expressed in normal tissue, but their expression and activity increase dramatically during wound healing as a result of a change in matrix composition, inflammation, and repair. Pancreatitis refers to inflammation of the pancreas resulting in an imbalance in its normal function. MMPs are involved in events like chronic inflammation, fibrosis, and resolution of the disease. There have been substantial advances in understanding the pathogenesis of acute and chronic pancreatitis, because of the recent scientific progress in the underlying genetic, cellular, and molecular pathophysiology. This study will provide an evidence-based review of the importance of MMPs in pancreatitis.