Evaluation of aphrodisiac activity of yellow ginseng (Rennelia elliptica Korth.) root ethanol extract in male DDY mice (Mus musculus)

Abstract

The root bark of yellow ginseng (Rennellia elliptica Korth.) is traditionally used as tonic and aphrodisiac by local people in West Kalimantan, Indonesia. This study determined the aphrodisiac activity of the ethanol extract of yellow ginseng root in male DDY mice. A Completely Randomized Design was used in this study, with 5 treatments, i.e., negative control (1% Na-CMC), positive control (sildenafil citrate) (5 mg/kg BW), yellow ginseng ethanol extract (50 mg/kg), yellow ginseng ethanol extract (100 mg/kg BW), yellow ginseng ethanol extract (250 mg/kg BW). The treatment was administered orally once a day by oral gavage. The duration of extract administration was 3, 5, and 10 days. The results showed that the administration of yellow ginseng ethanol extract at a dose of 250 mg/kg BW for 3 days increased libido as an indication of aphrodisiac activity. The administration of yellow ginseng extract for 10 days indicated prolonged ejaculation. However, this result was not statistically significant (p>0.05) compared to negative and positive control treatments.