Maternal serum pregnancy-associated plasma protein - A concentration at 11-14 weeks of gestation of women with common congenital anatomic uterine abnormalities

Abstract

Objectives: To evaluate maternal serum pregnancy-associated plasma protein-A (PAPP-A) levels at 11-14 weeks of gestation in women with common congenital anatomic uterine abnormalities (AUAs). Methods: First trimester screening markers were compared between 12 AUA pregnancies and 60 age matched controls. Results: PAPP-A level and birth weight were significantly lower in AUA compared to control pregnancies (P < 0.001). Conclusion: Our findings suggest that AUA pregnancies are associated with low first trimester maternal serum PAPP-A concentrations.