The synthesis and characterisation of 2-methyl-N- ((4-methylpyridine-2-yl)carbamothiol)benzamide: Its preparation with antibacterial study

Abstract

The compound, 2-methyl-N-((4-methylpyridin-2-yl)carbamothioyl)benzamide was derived from ortho-toluylchloride and 2-amino-4-picoline. It was fully crystallised and characterised on the basis of elemental analysis, X-ray crystallography and spectroscopic techniques namely infra-red, Uv-Vis and nuclear magnetic resonance. The melting point was in the range of 164.9°C-165.8°C. The Fourier transform infrared (FTIR) analysis shows the following vibrational frequencies for ν(N-H), ν(C=O), ν(C-N) and ν(C=S) at 3237 cm-1, 1683 cm-1, 1329 cm-1 and 1154 cm-1 respectively. 1H NMR results showed chemical shifts at 9.140 ppm and 12.983 ppm for the two N-H protons. Single crystal X-ray diffraction studies on the compound showed it to be a rigid molecule due to the presence of internal hydrogen bonding. The compound shows antibacterial activity towards gram positive and gram negative bacteria.