Bioproduction of sorbicillin derivatives from marine Trichoderma sp.

Abstract

The variability of sorbicillin derivatives production by marine Trichoderma sp., isolated from the sponge Agelas dispar J., was studied using six different culture media to find a good medium for biomass production, particularly of trichodimerol, bislongiquinolide and bisvertinol. A simple and rapid convenient method for identification, quantification and validation of the sorbicillin derivatives in ethyl acetate extracts has been applied by using RP-HPLC coupled with diode array detection. © 2008 Verlag der Zeitschrift für Naturforschung.