Four new 3,5-cyclosteroidal saponins from Dracaena surculosa

Abstract

Further search for steroidal compounds contained in Dracaena surculosa (Agavaceae) led to the isolation of two new 3,5-cyclospirostanol saponins (1, 2) and two new 3,5-cyclofurostanol saponins (3, 4). Their structural assignment was established by spectroscopic analysis and a few chemical transformations as (24S,25R)-1β-[(β-D-fucopyranosyl)oxy]-6β-hydroxy-3α, 5α-cyclospirostan-24-yl β-D-glucopyranoside (1), (24S,25R)-1β- [(β-D-glucopyranosyl)oxy]-6β-hydroxy-3α,5α-cyclospirostan- 24-yl β-D-glucopyranoside (2), (25S)-1β-[(β-D-glucopyranosyl)oxy] -6β-hydroxy-22α-methoxy-3α,5α-cyclofurostan-26-yl β-D-glucopyranoside (3), and (25S)-1β-[(β-D-fucopyranosyl)oxy]- 6β-hydroxy-22α-methoxy-3α,5α-cyclofurostan-26-yl β-D-glucopyranoside (4), respectively. © 2002 Pharmaceutical Society of Japan.