Artificial electron carriers for photoenzymatic synthesis under visible light

Abstract

NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3-substituted pyridine ring have been investigated. 3-Acetylpyridine adenine dinucleotide and 3-pyridinealdehyde adenine dinucleotide were photochemically reduced much more efficiently than NAD, while their reduced products showed coenzyme activity comparable to natural NAD. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.