Raman spectroscopy provides a noninvasive approach for determining biochemical composition of the pregnant cervix in vivo

Abstract

The molecular changes that occur with cervical remodelling during pregnancy are not completely understood. This study reviews Raman spectroscopy, an optical technique for detecting changes in the pregnant cervix, and reports preliminary studies on cervical remodelling in mice that suggest that the technique provides advantages over other methods. Conclusion Raman spectroscopy is sensitive to biochemical changes in the pregnant cervix and has high potential as a tool for detecting premature cervical remodelling in pregnant women. ©2014 Foundation Acta Pædiatrica. Published by John Wiley & Sons Ltd.