UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation

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Abstract

Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2. © 2014 Macmillan Publishers Limited. All rights reserved.

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Militti, C., Maenner, S., Becker, P. B., & Gebauer, F. (2014). UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation. Nature Communications, 5. https://doi.org/10.1038/ncomms5762

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