Evaluation of the ameliorative effect of Cinnamon Cassia against metabolic disorder and thyroid hormonal disruption following treatment with difenoconazole fungicide in the male albino rats.

Abstract

The present study aimed to investigate the deleterious effects of difenoconazole exposure involving the blood glucose level and lipid profile indices [i.e. TC, TAG, LDL-C, VLDL-C, and HDL-C]as well as renal function markers and thyroid hormonal level (T4&T3) in male albino rats after 28 days of treatments. Therefore, we also evaluate the ameliorative effect of aqueous extract of cinnamon (AEC) as a prophylactic agent against metabolic disorders including hyperglycemia and dyslipidemia as well as the alterations in the renal function markers (creatinine and urea) and the thyroid hormone levels in rats flowering treatment with difenoconazole. Results revealed that treating rats with difenoconazole induced a significant increase in the level of blood glucose and so the lipid profile indices i.e. TC, TAG, LDL-C, and VLDL-C, and a marked decrease in the level of LDL-C, in addition, a significant elevation in the levels of creatinine and urea was observed. In contrast, there is a significant decrease in the levels of T4 and T3 in difenoconazole-treated rats. Pre-treatments with AEC alleviate the harmful effects of difenoconazole treatment revealed by reducing the blood glucose level (hypoglycemia) and lipid profile parameters as well as the biomarkers of renal function and improvements the hypothyroidism state via elevating the levels of T4 and T3 in comparison with difenoconazole treatment. Therefore, these findings indicated the safety and useful effects of cinnamon extract for preventing the development of lipid metabolic disorders and hypothyroidism state, consequently attenuated its complications involved diabetes and cardiovascular disease (CHD).