A convenient synthesis of 2-methoxycarbonyl-5-iodobenzene sulfonamide

Abstract

A convenient and concise synthesis of 2-methyl-5-nitrobenzene sulfonamide can be achieved by sulfochlorination and ammoniation with p-nitrotoluene as raw materials for an 81.2 % yield. 6-Aminosaccharin can be produced via oxidation and reduction in a 64.3 % yield and then the iodination using potassium iodide can afford 6-iodosaccharin with a 70.8 % yield. 2-Methoxycarbonyl-5-iodobenzene sulfonamide can be produced via esterification in a 94.1 % yield.