Long non-coding RNA CRNDE and toll-like receptor 3 correlate with disease severity, inflammation, and mortality in sepsis

13Citations
Citations of this article
13Readers
Mendeley users who have this article in their library.

Abstract

Objective: This study aimed to assess the interaction between long non-coding RNA colorectal neoplasia differentially expressed (lncRNA CRNDE) and toll-like receptor 3 (TLR3), and assess their correlations with disease severity, inflammation, and 28-days mortality in sepsis patients. Methods: We consecutively enrolled 146 sepsis patients and 146 healthy controls (HCs), and collected their peripheral blood mononuclear cells to detect lncRNA CRNDE and TLR3 expressions using reverse transcription quantitative polymerase chain reaction. LncRNA CRNDE and TLR3 in sepsis patients were classified into four clusters according to quantile expressions (Quantile 1 (0%-24%), Quantile 2 (25%-50%), Quantile 3 (50%-74%), and Quantile 4 (75%-100%)) for correlation analysis. Results: LncRNA CRNDE was upregulated in sepsis patients compared with HCs, and it showed good value in differentiating sepsis patients form HCs by receiver operating characteristic curve analysis. In sepsis patients, lncRNA CRNDE positively correlated with acute pathologic and chronic health evaluation II (APACHE II) score and sequential organ failure assessment (SOFA) score, as well as serum creatinine (Scr). As for inflammation, lncRNA CRNDE positively correlated with C-reactive protein (CRP), tumor necrosis factor-α (TNF-α), interleukin (IL)-1β, IL-6, and IL-8. Regarding mortality, lncRNA CRNDE positively correlated with 28-days mortality. Furthermore, lncRNA CRNDE positively correlated with TLR3, and TLR3 positively associated with APACHE II score, SOFA score, Scr, albumin, CRP, TNF-α, IL-1β, IL-6, IL-8, and 28-days mortality in sepsis patients. Conclusion: LncRNA CRNDE interacts with TLR3, both of which correlate with advanced disease severity, inflammation, and higher 28-days mortality in sepsis patients.

References Powered by Scopus

The third international consensus definitions for sepsis and septic shock (sepsis-3)

18478Citations
N/AReaders
Get full text

The authors reply

581Citations
N/AReaders
Get full text

TLR3 is an endogenous sensor of tissue necrosis during acute inflammatory events

401Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Serum exosomal long noncoding RNA CRNDE as a prognostic biomarker for hepatocellular carcinoma

27Citations
N/AReaders
Get full text

Long Non-Coding RNAs as Biomarkers and Therapeutic Targets in Sepsis

27Citations
N/AReaders
Get full text

Interaction between non-coding RNAs and Toll-like receptors

18Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Yang, J., Liu, W., Xu, M., & Yu, L. (2020). Long non-coding RNA CRNDE and toll-like receptor 3 correlate with disease severity, inflammation, and mortality in sepsis. Journal of Clinical Laboratory Analysis, 34(9). https://doi.org/10.1002/jcla.23360

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 3

75%

Researcher 1

25%

Readers' Discipline

Tooltip

Medicine and Dentistry 4

50%

Biochemistry, Genetics and Molecular Bi... 3

38%

Immunology and Microbiology 1

13%

Save time finding and organizing research with Mendeley

Sign up for free