Formulation and evaluation of transdermal ultradeformable vesicles of aspirin

Abstract

Transfersomes are incredibly elastic and deformable vesicles composed of phos-pholipids and edge activators. This study proposed aspirin-loaded transfersomes for transdermal administration to prevent gastrointestinal side effects, boost drug permeation rate, and extend drug action. The formulations were prepared via the thin-film hydration method using soy lecithin as a vesicle forming agent and tween 80 as an edge activator. The formulation trials were optimized by ‘Custom design’ JMP SW13. The optimum formulation yielded a vesicle size of 74.4 nm, a zeta potential of-27.4 mV, and a % entrapment efficiency of 90.5%±0.25 with a drug release of 88.65 %±0.34. A 1% carbopol gel incorporated the optimum formula. The homogeneous gel had a drug content of 95.8±1.5 %, a viscosity of 1762cP, a pH of 5.74±0.78, and % a drug release of 85.5%±0.85. The study concluded that trans-dermal transfersomes would be a promising approach to treating angina.