Abstract
We proposed a strategy of photooxidizer-reduction activated alkylator (P-A) hybrid molecule to develop novel oxygen-independent photosensitizers. Two prototypes of such photosensitizers camptothecin-indolequinone (CPT-IQ) and camptothecin-nitrofuryl (CPT-NF) was designed and prepared. A mechanism of photo-induced oxidation and alkylation of 2'-deoxyguanosine by CPT-IQ was investigated. CPT-NF was confirmed to effectively induce DNA cleavage via 365-nm UV irradiation both under normaxia and hypoxia.
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CITATION STYLE
Zhang, Z., Haruna, K. I., Ito, T., Hatta, H., & Nishimoto, S. I. (2007). Development of novel oxygen-independent photosensitizers. Nucleic Acids Symposium Series (2004), (51), 229–230. https://doi.org/10.1093/nass/nrm115
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