Striatal BOLD and midfrontal theta power express motivation for action

Abstract

Action selection is biased by the valence of anticipated outcomes. To assess mechanisms by which these motivational biases are expressed and controlled, we measured simultaneous EEG-fMRI during a motivational Go/NoGo learning task (N = 36), leveraging the temporal resolution of EEG and subcortical access of fMRI. VmPFC BOLD encoded cue valence, importantly predicting trial-by-trial valence-driven response speed differences and EEG theta power around cue onset. In contrast, striatal BOLD encoded selection of active Go responses and correlated with theta power around response time. Within trials, theta power ramped in the fashion of an evidence accumulation signal for the value of making a "Go"response, capturing the faster responding to reward cues. Our findings reveal a dual nature of midfrontal theta power, with early components ref lecting the vmPFC contribution to motivational biases, and late components ref lecting their striatal translation into behavior, in line with inf luential recent "value of work"theories of striatal processing.