Abstract
With the intent of achieving greater spatiotemporal control of PROTAC-induced protein degradation, a light-activated degrader was designed by photocaging an essential E3 ligase binding motif in a BRD4 targeting PROTAC. Proteolysis was triggered only after a short irradiation time, the kinetics of which could be monitored by live-cell video microscopy.
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CITATION STYLE
APA
Kounde, C. S., Shchepinova, M. M., Saunders, C. N., Muelbaier, M., Rackham, M. D., Harling, J. D., & Tate, E. W. (2020). A caged E3 ligase ligand for PROTAC-mediated protein degradation with light. Chemical Communications, 56(41), 5532–5535. https://doi.org/10.1039/d0cc00523a
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