Vaccines against seasonal and pandemic influenza and the implications of changes in substrates for virus production

Abstract

Influenza virus changes constantly, making vaccine production challenging. Changing the growth substrate from eggs to cell culture raises issues at all stages of the process, from surveillance to the assay of vaccines. The pandemic threat-first H5N1, then HlNl-encouraged a review of methods and brought issues into sharp relief. © 2010 by the Infectious Diseases Society of America. All rights reserved.