Regulation of mammalian target of rapamycin complex 1 by Bcl-2 and Bcl-XL proteins

Abstract

Background:mTORC1 is a protein kinase that plays a central role in cell growth and metabolism. Results:mTORC1 signaling activity is affected by expression levels of two apoptotic proteins, Bcl-2 and Bcl-XL. Conclusion:Bcl-2 and Bcl-XL control mTORC1 activity by affecting the binding of mTORC1 with its inhibitor FKBP38. Significance:The novel cross-talk between Bcl-2/XL and mTORC1 signaling is likely to play an important role in cancer development. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.