Aqueous solubility of liquid monoterpenes at 293 K and relationship with calculated log P value

Abstract

Aqueous solubility is often a limiting factor in any concentration- dependent process and n-octanol/water partition coefficient, usually expressed as log P, is equilibrium between surrogate of nonaqueous biophases and water phase. The aqueous solubility of seven liquid monoterpenes: (±)-β- citronellol, (±)-linalool, linalyl acetate, ( - )-α-pinene, ( - )-β-pinene, eucalyptol and terpinen-4-ol were experimentally determined at 293 K. The obtained aqueous solubility data correlate well with log P values calculated by ACD/Log P software. © 2006 The Pharmaceutical Society of Japan.