Chronic Lymphocytic Leukemia with SF3B1 Mutation

Abstract

scopic ultrasound-guided fine-needle aspiration of cystic or solid lesions along the upper gastro-intestinal tract or mediastinum show a low prev-alence of procedure-related bacteremia. 1-4 Aspi-ration of suspected mediastinal cysts should be undertaken with caution. The American Society for Gastrointestinal Endoscopy recommends the use of antibiotic prophylaxis periprocedurally and postprocedurally (for 3 to 5 days) in all patients undergoing endoscopic ultrasound-guided fine-needle aspiration of mediastinal cysts (grade of rec-ommendation, 1C; intermediate-strength recom-mendation). 5 In a large North American series (which included 22 patients with mediastinal cysts who underwent endoscopic ultrasound-guided fine-needle aspiration) that involved antibiotic pro-phylaxis, there were no cases of infectious com-plications related to fine-needle aspiration. 2 1. Wildi SM, Hoda RS, Fickling W, et al. Diagnosis of benign cysts of the mediastinum: the role and risks of EUS and FNA. Gastrointest Endosc 2003;58:362-8. 2. Fazel A, Moezardalan K, Varadarajulu S, Draganov P, Eloubeidi MA. The utility and the safety of EUS-guided FNA in the evalu-ation of duplication cysts. Gastrointest Endosc 2005;62:575-80. 3. Banerjee S, Shen B, Baron T, et al. Antibiotic prophylaxis for GI endoscopy. Gastrointest Endosc 2008;67:791-8. 4. Diehl DL, Cheruvuttath R, Facktor MA, Go BD. Infection after endoscopic ultrasound-guided aspiration of mediastinal cysts. Interact Cardiovasc Thorac Surg 2010;10:338-40. 5. Adler DG, Jacobson BC, Davila RE, et al. ASGE guideline: complications of EUS. Gastrointest Endosc 2005;61:8-12. [Erra-tum, Gastrointest Endosc 2005;61:502.]