The effects of different social conditions on breast cancer induction in three genetic types of mice by dibenz[A, H]anthracene and a comparison with breast carcinogenesis by 3-methylcholanthrene

Abstract

Mice of 3 genetic types, maintained under different social conditions, were given 8 skin paintings of 05 ml. saturated solution of dibenz[a, h]anthracene in olive oil at fortnightly intervals. Breast tumours appeared with rates characteristic for each genetic type. In C57Bl they were slow to appear, with a long latent period, but were enhanced by forced breeding. In IF mice they appeared at the most rapid rate, with the shortest latent period, and in this strain lactation was inhibitory. In the F1 (C57Bl × IF) hybrids the rate of appearance was slower than in IF mice, the latent period was longer and lactation was extremely inhibitory. The results are compared with those previously obtained after treatment of similar mice with 3-methylcholanthrene. I wish to thank the Birmingham Branch of the British Empire Cancer Campaign for Research for support of this work. © 1967, The British Empire Cancer Campaign for Research. All rights reserved.