Leimyosarcoma of the urinary bladder. 13 years after cyclophosphamide therapy for Hodgkin's disease

Abstract

A leiomyosarcoma of the urinary bladder occurred in a 17‐year‐old boy who was treated with a total dose of 67 g cyclophosphamide over a period of 5 years for Hodgkin's disease diagnosed at the age of 4. Cyclophosphamide was discontinued at the age of 9 because of gross hematuria, and intermittent hematuria recurred 8 years after (at the age of 17) the cessation of this drug. A large exophytic tumor found in the urinary bladder was diagnosed as leiomyosarcoma by light and electron microscopic studies. In addition, there were microscopic features of long‐term cyclophosphamide toxicity throughout the bladder wall. Copyright © 1985 American Cancer Society