Synthesis, characterization and antimicrobial activity of cobalt metal complex against multi drug resistant bacterial and fungal pathogens

Abstract

Cobalt complex with histidine ligand was synthesized and physico-chemically characterized by solubility testing, melting point, UV-spectra and FTIR. The synthesized metal complex was evaluated for in-vitro antibacterial and antifungal activity against the multidrug resistant pathogens, such as Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, E. coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus and Candida albicans. The metal complex showed the significant antibacterial and antifungal activity comparison with commercial antibiotics. Further work can be extended through In-silico docking of this metal complex and bacterial, fungal genome which can be given a better idea about genome metal interaction in molecular level.Ostvarena je sinteza kompleksa jona kobalta i histidina kao liganda koji je fiziko-hemijski okarakterisan (odredjena je njegova rastvorljivost, tacka topljenja, a i snimljeni su njegovi UV i IC spektri). In vitro antibakterijska i antifungalna aktivnost sintetisanog kompleksa je testirana na visestruko otpornim patogenim sojevima, kao sto su: Pseudomonas aeruginosa, Vibrio cholerae, Salmonella typhi, Escherichia coli, Klebsiella pneumonia, Staphylococcus aureus, Aspergillus niger, Aspergillus flavus i Candida albicans. Kompleks je pokazao znacajnu antibakterijsku i antifungalnu aktivnost u poredjenju sa komercijalnim antibioticima koji su paralelno testirani sa njim. Dalja istrazivanja u smislu in silico ekperimenata bi pruzila informacije o interakciji ovog kompleksa kobalta sa genomom bakterija i gljivica na molekulskom nivou.